Best Hypoallergenic Mattress Covers

Looking for the best hypoallergenic mattress covers? We’ve curated a list of top options to help you find the perfect cover for a clean, safe, and comfortable sleep.

Protect your sleep with the best hypoallergenic mattress covers. These covers keep your mattress clean and safe. They block allergens, bed bugs, and dust mites.

Hypoallergenic covers are easy to care for. Most are machine washable and durable. They fit snugly on your mattress, ensuring comfort and protection.

Discover the perfect cover for your needs. Whether you want waterproof protection or allergy relief, we’ve got you covered. Read on to find the best option for a better night’s sleep.

List of Top 10 Hypoallergenic Mattress Covers

Image Title Best For Price
HOSPITOLOGY PRODUCTS Mattress Encasement - Zippered Bed Bug Dust Mite Proof Hypoallergenic - Sleep Defense System - Queen - Waterproof - Stretchable - Standard 12 HOSPITOLOGY PRODUCTS Mattress Encasement – Zippered Bed Bug Dust Mite Proof Hypoallergenic – Sleep Defense System – Queen – Waterproof – Stretchable – Standard 12″ Depth – 60″ W x 80″ L

This HOSPITOLOGY Mattress Encasement is perfect for anyone who wants a clean, healthy sleep. It’s great for allergy sufferers, families with kids, or anyone needing waterproof protection.

AllerEase Waterproof Mattress Protector, Maximum Allergy Mattress Protector, Queen Mattress Cover AllerEase Waterproof Mattress Protector, Maximum Allergy Mattress Protector, Queen Mattress Cover

The AllerEase Waterproof Mattress Protector is perfect for families with kids or pets, allergy sufferers, and anyone wanting to keep their mattress clean and fresh. It’s easy to use and machine washable, making it a great choice for everyone.

100% Waterproof Queen Mattress Protector Breathable Cooling 3D Air Fabric Mattress Cover Smooth Soft Hypoallergenic Noiseless Bed Cover Machine Washable Vinyl Free, 8-21'' Deep Pocket 100% Waterproof Queen Mattress Protector Breathable Cooling 3D Air Fabric Mattress Cover Smooth Soft Hypoallergenic Noiseless Bed Cover Machine Washable Vinyl Free, 8-21” Deep Pocket

This queen mattress protector is perfect for anyone who wants to keep their mattress clean, fresh, and long-lasting. It’s great for families, allergy sufferers, or anyone who values comfort and ease.

Amazon Basics Hypoallergenic Quilted Mattress Topper Pad, Cover 18 Inches Deep, Full, White Amazon Basics Hypoallergenic Quilted Mattress Topper Pad, Cover 18 Inches Deep, Full, White

This mattress topper is perfect for anyone who wants extra comfort and protection for their mattress. It’s great for allergy sufferers and those who want easy care.

AllerEase Waterproof Mattress Protector, Maximum Allergy Mattress Protector, Twin Mattress Cover AllerEase Waterproof Mattress Protector, Maximum Allergy Mattress Protector, Twin Mattress Cover

The AllerEase Waterproof Mattress Protector is perfect for anyone who wants to keep their mattress clean and allergy-free. It’s great for kids, pets, or anyone with allergies.

AllerEase Ultimate Allergy Protection and Comfort Zippered Mattress Protector, Queen AllerEase Ultimate Allergy Protection and Comfort Zippered Mattress Protector, Queen

The AllerEase Ultimate Allergy Protection and Comfort Zippered Mattress Protector is perfect for anyone who wants a clean, comfortable, and protected mattress. It’s great for allergy sufferers, busy families, or anyone who wants easy care and long-lasting comfort.

AllerEase Platinum Zip-Off Top Waterproof Mattress Protector Queen Size 360 Degree Zipper Allergen Barrier Temperature Balancing Luxurious Plush Top Separately Machine Washable Mattress Cover (White) AllerEase Platinum Zip-Off Top Waterproof Mattress Protector Queen Size 360 Degree Zipper Allergen Barrier Temperature Balancing Luxurious Plush Top Separately Machine Washable Mattress Cover (White)

This AllerEase Platinum Mattress Protector is perfect for anyone who wants to keep their mattress clean, comfortable, and protected. It’s great for allergy sufferers, busy families, or anyone who wants a cooler, drier sleep.

SureGuard Queen Size Mattress Protector - 100% Waterproof, Hypoallergenic - Premium Fitted Cotton Cover - Smooth SureGuard Queen Size Mattress Protector – 100% Waterproof, Hypoallergenic – Premium Fitted Cotton Cover – Smooth

The SureGuard Queen Size Mattress Protector is perfect for anyone who wants to keep their mattress clean and fresh. It’s great for families, pet owners, or anyone with allergies.

AllerEase Ultimate Allergy Protection and Comfort Zippered Mattress Protector, Twin AllerEase Ultimate Allergy Protection and Comfort Zippered Mattress Protector, Twin

The AllerEase Ultimate Allergy Protection and Comfort Zippered Mattress Protector is perfect for anyone who wants to keep their mattress clean and fresh. It’s great for kids, pets, or anyone with allergies, offering waterproof protection and comfort.

King Size Mattress Protector Bed Bug Waterproof Zippered Cover - Hypoallergenic Premium Quality Encasement Protects Against Liquids, Dust - Breathable, Noiseless White King Size Mattress Protector Bed Bug Waterproof Zippered Cover – Hypoallergenic Premium Quality Encasement Protects Against Liquids, Dust – Breathable, Noiseless White

This King Size Mattress Protector is perfect for families with kids or pets, anyone with allergies, or those who want to keep their mattress clean and dry. It’s easy to use, quiet, and lasts a long time.

Detailed Reviews

Discover the top 10 hypoallergenic mattress covers in our expert-curated guide. Each product is thoroughly reviewed for comfort, protection, and value. Whether you need allergy relief or waterproof features, we’ve got you covered. Find the perfect fit for a cleaner, healthier sleep today!

1. HOSPITOLOGY PRODUCTS Mattress Encasement – Zippered Bed Bug Dust Mite Proof Hypoallergenic – Sleep Defense System – Queen – Waterproof – Stretchable – Standard 12″ Depth – 60″ W x 80″ L

HOSPITOLOGY PRODUCTS Mattress Encasement - Zippered Bed Bug Dust Mite Proof Hypoallergenic - Sleep Defense System - Queen - Waterproof - Stretchable - Standard 12

Protect your sleep with the Hospitology Products Mattress Encasement. It fits Queen mattresses from 12″ to 18″ deep. The zippered design keeps it secure.

This cover is 100% waterproof on all sides. It blocks bed bugs and dust mites. The soft polyester fabric keeps you cool and comfy.

Machine washable for easy care. It comes with a 5-year warranty. Enjoy better sleep with this hypoallergenic shield.

Pros Cons
  • 100% Waterproof protection on all sides.
  • Stretches to fit any Queen mattress size.
  • Machine washable for easy cleaning.
  • Helps reduce allergens and improve sleep quality.
  • Made with soft, breathable fabric for comfort.
  • Not for extra-deep mattresses over 18″ depth.
  • May make some noise when moving on the bed.
  • Initial plastic-like smell may need airing out.

Perfect For:

This HOSPITOLOGY Mattress Encasement is perfect for anyone who wants a clean, healthy sleep. It’s great for allergy sufferers, families with kids, or anyone needing waterproof protection.

Ready to Purchase?

2. AllerEase Waterproof Mattress Protector, Maximum Allergy Mattress Protector, Queen Mattress Cover

AllerEase Waterproof Mattress Protector, Maximum Allergy Mattress Protector, Queen Mattress Cover

The AllerEase Waterproof Mattress Protector is designed to keep your mattress clean and safe. It prevents 99.9% of unhealthy particles from entering your mattress.

This protector is waterproof, which means it stops liquids from ruining your mattress. It is also made with breathable fabric for comfort. You can enjoy a good night’s sleep without worrying about allergies.

With FlexFit technology, this mattress protector fits snugly on your bed. It is soft, quiet, and easy to wash. The AllerEase mattress protector is a great choice for anyone looking for allergy relief and protection.

Pros Cons
  • Protects against 99.9% of allergens.
  • Waterproof to keep your mattress safe.
  • Breathable fabric for a comfortable sleep.
  • Snug fit with quiet cover for restful nights.
  • Recommended by allergists for peace of mind.
  • May not fit all mattress depths.
  • Waterproof layer might feel warm.
  • Quiet cover still audible sometimes.

Perfect For:

The AllerEase Waterproof Mattress Protector is perfect for families with kids or pets, allergy sufferers, and anyone wanting to keep their mattress clean and fresh. It’s easy to use and machine washable, making it a great choice for everyone.

Ready to Purchase?

3. 100% Waterproof Queen Mattress Protector Breathable Cooling 3D Air Fabric Mattress Cover Smooth Soft Hypoallergenic Noiseless Bed Cover Machine Washable Vinyl Free, 8-21” Deep Pocket

100% Waterproof Queen Mattress Protector Breathable Cooling 3D Air Fabric Mattress Cover Smooth Soft Hypoallergenic Noiseless Bed Cover Machine Washable Vinyl Free, 8-21'' Deep Pocket

Protect your mattress with our 100% Waterproof Queen Mattress Protector. It is made to keep your bed fresh and clean. Enjoy a worry-free sleep every night!

This mattress cover is hypoallergenic and safe, certified by OEKO-TEX. Its soft bamboo rayon and durable polyester blend provide great comfort and breathability.

Cleaning is easy with this machine washable protector. It can handle over 500 washes while staying waterproof, making it last for years!

Pros Cons
  • 100% waterproof for ultimate mattress protection.
  • Hypoallergenic materials ensure safe sleep.
  • Breathable design keeps you cool and comfy.
  • Machine washable for easy cleaning.
  • 10-year warranty for peace of mind.
  • Not for extra-thick mattresses over 21 inches.
  • Bamboo blend may wear faster than all-cotton options.
  • Tumble dry only at low heat, no high-temp drying.

Perfect For:

This queen mattress protector is perfect for anyone who wants to keep their mattress clean, fresh, and long-lasting. It’s great for families, allergy sufferers, or anyone who values comfort and ease.

Ready to Purchase?

4. Amazon Basics Hypoallergenic Quilted Mattress Topper Pad, Cover 18 Inches Deep, Full, White

Amazon Basics Hypoallergenic Quilted Mattress Topper Pad, Cover 18 Inches Deep, Full, White

The Amazon Basics Hypoallergenic Quilted Mattress Topper Pad adds extra comfort to your bed. It is designed to fit full-sized mattresses that are up to 18 inches deep. This topper helps protect your mattress and makes sleeping more enjoyable.

Made from poly-cotton fabric, this topper is breathable and lightweight. It features a hypoallergenic fill that is great for people with allergies.

This product is easy to care for, as it is machine washable and safe for high temperatures. The knitted fabric sides ensure a secure fit on your mattress. Enjoy a better night’s sleep with this comfortable mattress topper!

Pros Cons
  • Hypoallergenic fill, perfect for allergy sufferers.
  • Secure fit on mattresses up to 18 inches deep.
  • Easy care: machine wash and dry, high-temperature safe.
  • OEKO-TEX certified, ensuring safety and quality.
  • Not for extra-deep mattresses over 18 inches.
  • Poly-cotton blend may not suit all fabric preferences.
  • Machine washing requires large-capacity washer/dryer.

Perfect For:

This mattress topper is perfect for anyone who wants extra comfort and protection for their mattress. It’s great for allergy sufferers and those who want easy care.

Ready to Purchase?

5. AllerEase Waterproof Mattress Protector, Maximum Allergy Mattress Protector, Twin Mattress Cover

AllerEase Waterproof Mattress Protector, Maximum Allergy Mattress Protector, Twin Mattress Cover

The AllerEase Waterproof Mattress Protector is designed to keep your mattress clean and safe. It blocks 99.9% of allergens and unhealthy particles. This protector is also waterproof, making it perfect for kids and pets.

The soft, breathable fabric ensures a comfortable night’s sleep. Plus, it is machine washable and comes with a Lifetime warranty.

Pros Cons
  • Blocks 99.9% of allergens for a cleaner sleep.
  • Waterproof shield keeps mattress safe from spills.
  • Breathable fabric ensures a cool, comfy rest.
  • Snug fit with quiet, soft FlexFit technology.
  • Not eco-friendly materials used in production.
  • Might slide slightly on certain mattress types.
  • Initial plastic smell may require airing out.

Perfect For:

The AllerEase Waterproof Mattress Protector is perfect for anyone who wants to keep their mattress clean and allergy-free. It’s great for kids, pets, or anyone with allergies.

Ready to Purchase?

6. AllerEase Ultimate Allergy Protection and Comfort Zippered Mattress Protector, Queen

AllerEase Ultimate Allergy Protection and Comfort Zippered Mattress Protector, Queen

The AllerEase Ultimate Allergy Protection and Comfort Zippered Mattress Protector keeps your mattress safe. It has a soft cotton top that is waterproof to guard against spills. This protector helps maintain a clean sleeping environment.

This mattress protector features temperature balancing technology. It wicks moisture away to keep you comfortable all night.

With flexfit elastic corners, it fits snugly on mattresses. It works well for various sizes, including Queen and King. Care is easy too; just machine wash and tumble dry.

Pros Cons
  • Waterproof top keeps your mattress safe from spills.
  • Comfortable cotton fabric for a better night’s sleep.
  • Temperature balancing technology for added comfort.
  • Easy care with machine wash and dry instructions.
  • Secure fit for various mattress sizes up to 17 inches.
  • Not breathable enough for hot sleepers.
  • Machine washing requires care to avoid damage.
  • Higher price than basic protectors.

Perfect For:

The AllerEase Ultimate Allergy Protection and Comfort Zippered Mattress Protector is perfect for anyone who wants a clean, comfortable, and protected mattress. It’s great for allergy sufferers, busy families, or anyone who wants easy care and long-lasting comfort.

Ready to Purchase?

7. AllerEase Platinum Zip-Off Top Waterproof Mattress Protector Queen Size 360 Degree Zipper Allergen Barrier Temperature Balancing Luxurious Plush Top Separately Machine Washable Mattress Cover (White)

AllerEase Platinum Zip-Off Top Waterproof Mattress Protector Queen Size 360 Degree Zipper Allergen Barrier Temperature Balancing Luxurious Plush Top Separately Machine Washable Mattress Cover (White)

The AllerEase Platinum Mattress Protector keeps your mattress clean and fresh. Its 360-degree zipper makes it easy to remove and wash. The luxurious plush top adds extra comfort to your sleep.

It’s waterproof to protect against spills and stains. The temperature-balancing fabric keeps you cool or warm as needed. Plus, it acts as a bed bug barrier for added peace of mind.

Pros Cons
  • Easy on and off with 360-degree zipper.
  • Super soft and comfy plush top.
  • Stays cool or warm for perfect sleep.
  • Keeps spills away, waterproof protection.
  • Blocks tiny bugs for a cleaner bed.
  • Top may be difficult to wash.
  • Zipper could be tricky to use.

Perfect For:

This AllerEase Platinum Mattress Protector is perfect for anyone who wants to keep their mattress clean, comfortable, and protected. It’s great for allergy sufferers, busy families, or anyone who wants a cooler, drier sleep.

Ready to Purchase?

8. SureGuard Queen Size Mattress Protector – 100% Waterproof, Hypoallergenic – Premium Fitted Cotton Cover – Smooth

SureGuard Queen Size Mattress Protector - 100% Waterproof, Hypoallergenic - Premium Fitted Cotton Cover - Smooth

The SureGuard Queen Size Mattress Protector keeps your mattress safe and clean. It is 100% waterproof, blocking spills and stains. With a smooth cotton top, it feels great to sleep on.

This protector is easy to clean and can be machine washed. It fits snugly on all mattress sizes and is GreenGuard Gold certified for safety.

Pros Cons
  • 100% Waterproof shields against spills, stains, and accidents.
  • Hypoallergenic barrier blocks dust, dirt, and dander.
  • Soft & Noiseless cotton keeps your mattress feeling fresh.
  • Machine Washable for easy cleaning and long-lasting use.
  • Not for heavy soiling.
  • May not fit extra-thick mattresses.
  • Cotton can be warm in summer.

Perfect For:

The SureGuard Queen Size Mattress Protector is perfect for anyone who wants to keep their mattress clean and fresh. It’s great for families, pet owners, or anyone with allergies.

Ready to Purchase?

9. AllerEase Ultimate Allergy Protection and Comfort Zippered Mattress Protector, Twin

AllerEase Ultimate Allergy Protection and Comfort Zippered Mattress Protector, Twin

The AllerEase Ultimate Allergy Protection and Comfort Zippered Mattress Protector is perfect for your twin mattress. It has a waterproof top to guard against spills. This protector helps keep your mattress fresh and clean.

With temperature balancing technology, it keeps you comfortable all night long. The FlexFit corners ensure a snug fit for different mattress sizes.

Pros Cons
  • Waterproof cotton top protects mattress from spills and stains.
  • Temperature balancing tech keeps you cool and comfortable.
  • FlexFit elastic corners ensure a perfect, snug fit.
  • Easy care instructions for hassle-free cleaning.
  • Not breathable enough for hot sleepers.
  • Machine washing required often for clean sleep.
  • No iron option, wrinkles may show.

Perfect For:

The AllerEase Ultimate Allergy Protection and Comfort Zippered Mattress Protector is perfect for anyone who wants to keep their mattress clean and fresh. It’s great for kids, pets, or anyone with allergies, offering waterproof protection and comfort.

Ready to Purchase?

10. King Size Mattress Protector Bed Bug Waterproof Zippered Cover – Hypoallergenic Premium Quality Encasement Protects Against Liquids, Dust – Breathable, Noiseless White

King Size Mattress Protector Bed Bug Waterproof Zippered Cover - Hypoallergenic Premium Quality Encasement Protects Against Liquids, Dust - Breathable, Noiseless White

Protect your mattress with our King Size Mattress Protector. This cover is waterproof, hypoallergenic, and completely encases your mattress on all sides.

It features a zippered design for easy installation. The soft fabric keeps your sleep quiet. Enjoy a clean, protected sleeping environment!

Pros Cons
  • Full zipper and Velcro seal keep pets and bugs out.
  • Waterproof lining blocks liquids, protects your mattress.
  • Soft, noiseless fabric for comfortable, undisturbed sleep.
  • Easy to install, machine washable, durable for long-lasting use.
  • Zipper might snag with frequent use.
  • Polyurethane lining could reduce breathability slightly.

Perfect For:

This King Size Mattress Protector is perfect for families with kids or pets, anyone with allergies, or those who want to keep their mattress clean and dry. It’s easy to use, quiet, and lasts a long time.

Ready to Purchase?

Buying Guide

Protect your sleep with the best hypoallergenic mattress covers. These covers keep your mattress clean and safe.

Choosing the right hypoallergenic mattress cover can improve your sleep and health. Here’s what to consider:

  • Material: Look for breathable fabrics like cotton or bamboo. They keep you cool and comfortable.
  • Waterproof: A waterproof cover protects against spills and accidents. It’s great for kids and pets.
  • Allergen Protection: Ensure it blocks dust mites, bed bugs, and other allergens for a healthier sleep.
  • Fit: Choose a cover that fits your mattress size snugly. Check for deep pockets if your mattress is thick.
  • Ease of Care: Machine washable covers are convenient. They save time and effort.
  • Durability: Look for durable materials that last long. Some come with warranties for added peace of mind.
  • Noise Level: Avoid covers that make noise when you move. Noiseless options ensure undisturbed sleep.
  • Certification: Check for hypoallergenic certifications like OEKO-TEX or GreenGuard Gold for safety.